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Phenotype Images associated with this Allele
Nomenclature
Symbol: Nat8f5b2b1702.1Clo
Name: N-acetyltransferase 8 (GCN5-related) family member 5; Bench to Bassinet Program (B2B/CVDC), mutation 1702, subline 1 Cecilia Lo
MGI ID: MGI:5696519
Synonyms: TLC
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1702-003-2 (E16.5) displays malaligned great arteries indicative of double outlet right ventricle (DORV) as confirmed by ECM imaging.b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
EFIC Summaryb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Serial 2D EFIC image stack in the coronal plane of 1702-003-2 (E16.5) reveals double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), biventricular hypertrophy, and coronary fistula.
Click thumbnail to play movie.		b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Mutant 1702-003-2 (E 16.5) displays abnormal lung lobation (2 lobes on right/1 lobe on left).b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Mutant 1702-003-2 (E 16.5) exhibits an omphalocoele and severe hydropsb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Mutant 1702-003-1 (E16.5) shows malaligned great arteries which is diagnosed as double outlet right ventricle by ECM imaging.b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
EFIC Summaryb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Serial 2D EFIC image stack in the coronal plane of 1702-003-1 (E16.5) reveals double outlet right ventricle with subaortic VSD {S,D,D}.
Click thumbnail to play movie.		b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Color flow spectral Doppler imaging of mutant 1702-003-1 in the frontal view shows both the aorta and pulmonary artery originating from the RV, with subaortic VSD and muscular VSD, indicating DORVb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Mutant 1702-003-3 (E 16.5) exhibits heterotaxy with mesocardia.b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
EFIC Summaryb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Serial 2D EFIC image stack in the coronal plane of 1702-003-3 (E16.5) reveals muscular VSD
Click thumbnail to play movie.		b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory