Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Kash5^{tm1b(KOMP)Wtsi}
Name:	KASH domain containing 5; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID:	MGI:5700363
Synonyms:	Kash5-null

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Small testes and narrow seminiferous tubules devloid of elongated spermatids and mature sperm in Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} males	Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N
	Homologue pairing is defective in Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} spermatocytes	Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N
	DNA double strand breaks persist in Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} testes	Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N
	Reduction in the association of telomeres with SUN1 in Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} spermatocytes	Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N
	Cytoplasmic dynein is not recruited to telomere attachement sites at the nuclear envelope of Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} spermatocytes	Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N
	Gametogenesis defect in Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} females	Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N

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