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Phenotype Images associated with this Allele
Nomenclature
Symbol: Tjp1tm1.1Whun
Name: tight junction protein 1; targeted mutation 1.1, Walter Hunziker
MGI ID: MGI:5749399
Synonyms: Tjp1flox
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Growth retardation and severe glomerulosclerosis in Tjp1tm1.1Whun/Tjp1tm1.1WhunTg(Nphs1-cre)33Mska/0 miceTjp1tm1.1Whun/Tjp1tm1.1Whun
Tg(Nphs1-cre)33Mska/0		involves: C57BL/6 * C57BL/6N * DBA/2
Compromised foot process interdigitation and aberrant distribution of the slit diaphragm components in Tjp1tm1.1Whun/Tjp1tm1.1Whun Tg(Nphs1-cre)33Mska/0 miceTjp1tm1.1Whun/Tjp1tm1.1Whun
Tg(Nphs1-cre)33Mska/0		involves: C57BL/6 * C57BL/6N * DBA/2
Slit diaphragms are absent in the maturing stage of Tjp1tm1.1Whun/Tjp1tm1.1WhunTg(Nphs1-cre)33Mska/0 podocytesTjp1tm1.1Whun/Tjp1tm1.1Whun
Tg(Nphs1-cre)33Mska/0		involves: C57BL/6 * C57BL/6N * DBA/2
Defects in the glomerulus, dilated renal tubules, global foot process effacement and absent slit diaphragm in Tjp1tm1.1Whun/Tjp1tm1.1Whun Tg(Nphs1-cre)33Mska/0 miceTjp1tm1.1Whun/Tjp1tm1.1Whun
Tg(Nphs1-cre)33Mska/0		involves: C57BL/6 * C57BL/6N * DBA/2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory