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Phenotype Images associated with this Allele
Nomenclature
Symbol: Cep120tm1.2Blnw
Name: centrosomal protein 120; targeted mutation 1.2, Baolin Wang
MGI ID: MGI:5749514
Synonyms: Cep120-
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Developmentof Cep120tm1.2Blnw/Cep120tm1.2Blnw embryos is delayed and the heart loops in the opposite directionCep120tm1.2Blnw/Cep120tm1.2Blnwinvolves: 129S6/SvEvTac * C57BL/6
Hydrocephalus, dilated brain ventricles, and smaller cerebellum in Cep120tm1.1Blnw/Cep120tm1.2BlnwTg(Nes-cre)1Atp/0 miceCep120tm1.1Blnw/Cep120tm1.2Blnw
Tg(Nes-cre)1Atp/0		involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Cerebellar hypoplasia in Cep120tm1.1Blnw/Cep120tm1.2BlnwTg(Nes-cre)1Atp/0 miceCep120tm1.1Blnw/Cep120tm1.2Blnw
Tg(Nes-cre)1Atp/0		involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Failed expansion of granule neuron progenitors in Cep120tm1.1Blnw/Cep120tm1.2BlnwTg(Nes-cre)1Atp/0 miceCep120tm1.1Blnw/Cep120tm1.2Blnw
Tg(Nes-cre)1Atp/0		involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Failed proliferation of granule neuron progenitors in Cep120tm1.1Blnw/Cep120tm1.2BlnwTg(Nes-cre)1Atp/0 cerebellumCep120tm1.1Blnw/Cep120tm1.2Blnw
Tg(Nes-cre)1Atp/0		involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Centriole duplication and ciliogenesis defects in Cep120tm1.2Blnw/Cep120tm1.2Blnw MEFsCep120tm1.2Blnw/Cep120tm1.2Blnwinvolves: 129S6/SvEvTac * C57BL/6
Failed centriole duplication, maturation, and ciliogenesis in cerebellar granule neuron progenitors and ependymal cells of Cep120tm1.1Blnw/Cep120tm1.2Blnw Tg(Nes-cre)1Atp/0 miceCep120tm1.1Blnw/Cep120tm1.2Blnw
Tg(Nes-cre)1Atp/0		involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory