Phenotype Images associated with this Gene

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Phenotype Images associated with this Gene

Symbol
Name
ID

Six2
sine oculis-related homeobox 2
MGI:102778

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Click on allele symbol for full phenotype details.

	Caption: Abnormal kidney development in Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice (details) Represented Alleles: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Yap1^tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: Abnormal nephron formation in Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice (details) Represented Alleles: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Yap1^tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: Impaired nephron induction in Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice (details) Represented Alleles: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Yap1^tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: S-shaped body is reduced in size in Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ nephrons (details) Represented Alleles: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Yap1^tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: Kidney abnormalities in Cdc42^tm1Brak/Cdc42^tm1Brak Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice (details) Represented Alleles: Cdc42^tm1Brak, cell division cycle 42; targeted mutation 1, Cord Brakebusch Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: Nephrogenesis abnormalities in Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺, Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ and double mutant mice (details) Represented Alleles: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Wwtr1^tm1Hmc, WW domain containing transcription regulator 1; targeted mutation 1, Helen McNeill Yap1^tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: Kidney development abnormalities in Cdc42^tm1Brak/Cdc42^tm1Brak Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice (details) Represented Alleles: Cdc42^tm1Brak, cell division cycle 42; targeted mutation 1, Cord Brakebusch Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: Hypoplasia and loss of glomeruli and proximal tubules in Wasl^tm2Sbs/Wasl^tm2Sbs Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ kidneys (details) Represented Alleles: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Wasl^tm2Sbs, WASP like actin nucleation promoting factor; targeted mutation 2, Scott B Snapper Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: Loss of foot processes in Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice (details) Represented Alleles: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Yap1^tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
	Caption: Decreased branching morphogenesis in Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ kidneys (details) Represented Alleles: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon Yap1^tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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