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Phenotype Images associated with this Gene
Symbol
Name
ID 		Pcsk6
proprotein convertase subtilisin/kexin type 6
MGI:102897


13 phenotype image(s) for Pcsk6 alleles
Showing image(s) 1 to 10 		Show   figures per page Next Last
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Caption: Mutant (E14.5) shows a malrotated heart which is diagnosed as superior-inferior ventricles by ECM histopathology. (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: Mutant (E14.5) shows abnormal arrangement of the outflow tracts which was diagnosed by ECM histopathology as double outlet right ventricle (DORV) with interrupted aortic arch (type C) and a hypoplastic pulmonary artery. (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: EFIC Summary (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: Serial 2D ECM image stack in the coronal plane of mutant (E14.5) reveals {A(I),A,D}, superior-inferior ventricles, double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), common atrium, interrupted aortic arch (type C), hypoplastic pulmonary artery (PA), aberrant right subclavian artery forming incomplete vascular ring. Single lung lobe, left sided inferior vena cava (IVC), total anomalous pulmonary venous return (TAPVR), and left lung isomerism.
Click thumbnail to play movie. (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: Mutant (E14.5) shows dextrogastria and asplenia. (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: Mutant (E14.5) exhibits hydrops and petechiae as well as severe craniofacial defects including microcephaly, proboscis, agnathia, and cyclopia (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: EFIC Summary (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: Serial 2D ECM image stack of (ED14.5) in the coronal plane revelas atrioventricular septal defect (AVSD), small LV, thick cushion like atrioventricular (AV) valve.
Click thumbnail to play movie. (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: Mutant (E14.5) exhibits hydrops and petechiae as well as severe craniofacial defects including hydrops, petechiae, microcephaly, proboscis, and agnathia (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Caption: Mutant (E14.5) has severe craniofacial defects consistent with otocephaly which include microcephaly with cyclopia, proboscis, and agnathia (details)
Represented Alleles:
Pcsk6b2b2830Clo, proprotein convertase subtilisin/kexin type 6; Bench to Bassinet Program (B2B/CVDC), mutation 2830 Cecilia Lo
Copyright: This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors. J:175213
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory