Phenotype Images associated with this Gene

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Phenotype Images associated with this Gene

Symbol
Name
ID

Cdkn2a
cyclin dependent kinase inhibitor 2A
MGI:104738

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Click on allele symbol for full phenotype details.

	Caption: Pancreatic tumors in Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0 and Kras^tm4Tyj/Kras^tm4Tyj Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Tg(Pdx1-cre)89.1Dam/0 mice (details) Represented Alleles: Cdkn2a^tm4Rdp, cyclin dependent kinase inhibitor 2A; targeted mutation 4, Ronald DePinho Kras^tm4Tyj, Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks Tg(Pdx1-cre)89.1Dam, transgene insertion 89.1, Douglas A Melton Trim33^tm1Los, tripartite motif-containing 33; targeted mutation 1, Regine Losson Copyright: This image is from Vincent DF, PLoS Genet 2009 Jul;5(7):e1000575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151781
	Caption: Degenerative phenotypes, including increased apoptosis in gastrointestinal crypts and germ cell depletion, in Terc^tm1Rdp/Terc^tm1Rdp and Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp mice (details) Represented Alleles: Cdkn2a^tm1Rdp, cyclin dependent kinase inhibitor 2A; targeted mutation 1, Ronald DePinho Terc^tm1Rdp, telomerase RNA component; targeted mutation 1, Ronald DePinho Copyright: This image is from Khoo CM, Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3931-6. Copyright 2007 National Academy of Sciences, U.S.A. J:120065
	Caption: Metastasis of primary squamous cell carcinoma to lymph nodes and lungs in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice (details) Represented Alleles: Cdkn2a^tm1Cjs, cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr Copyright: This image is from Kelly-Spratt KS, PLoS Biol 2004 Sep;2(8):E242, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:93298
	Caption: Tumor multiplicity and proliferation index in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs, Trp53^tm1Brd/Trp53^tm1Brd and Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Trp53^tm1Brd/Trp53^tm1Brd mice (details) Represented Alleles: Cdkn2a^tm1Cjs, cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr Trp53^tm1Brd, transformation related protein 53; targeted mutation 1, Allan Bradley Copyright: This image is from Kelly-Spratt KS, PLoS Biol 2004 Sep;2(8):E242, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:93298
	Caption: Abnormal retrolental tissue present in the eyes of neonatal Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice (details) Represented Alleles: Cdkn2a^tm1Cjs, cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr Copyright: This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215
	Caption: Retrolental tissue in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice contains mature hyaloid vascular structures and endothelial cells (details) Represented Alleles: Cdkn2a^tm1Cjs, cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr Copyright: This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215
	Caption: PHPV-like abnormalities develop in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mouse eyes (details) Represented Alleles: Cdkn2a^tm1Cjs, cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr Copyright: This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215
	Caption: Persistent hyperplastic primary vitreous (PHPV) in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice is p53 independent (details) Represented Alleles: Cdkn2a^tm1Cjs, cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr Trp53^tm1Tyj, transformation related protein 53; targeted mutation 1, Tyler Jacks Copyright: This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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