Phenotype Images associated with this Gene

About Help FAQ

Phenotype Images associated with this Gene

Symbol
Name
ID

Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
MGI:104878

Click on thumbnail to view full size image with links to phenotype annotations.
Click on allele symbol for full phenotype details.

	Caption: Prkar1a heterozygosity accelerates osteosarcoma development in Tg(Bglap2-TAg)1Rkho/0 mice (details) Represented Alleles: Prkar1a^tm1.2Lsk, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.2, Lawrence Kirschner Tg(Bglap2-TAg)1Rkho, transgene insertion 1, Rama Khokha Tg(Col1a1-cre)1Kry, transgene insertion 1, Gerard Karsenty Copyright: This image is from Molyneux SD, J Clin Invest 2010 Sep 1;120(9):3310-25 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:165282
	Caption: Bone tumorigenesis nd abundant osteoclasts in Prkar1a^tm1.2Lsk/Prkar1a⁺ Tg(Col1a1-cre)1Kry/0 mice (details) Represented Alleles: Prkar1a^tm1.2Lsk, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.2, Lawrence Kirschner Tg(Col1a1-cre)1Kry, transgene insertion 1, Gerard Karsenty Copyright: This image is from Molyneux SD, J Clin Invest 2010 Sep 1;120(9):3310-25 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:165282
	Caption: Osteosarcoma characterization in Tg(Bglap2-TAg)1Rkho/0 and Prkar1a^tm1.2Lsk/Prkar1a⁺ Tg(Col1a1-cre)1Kry/0 Tg(Bglap2-TAg)1Rkho/0 mice (details) Represented Alleles: Prkar1a^tm1.2Lsk, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.2, Lawrence Kirschner Tg(Bglap2-TAg)1Rkho, transgene insertion 1, Rama Khokha Tg(Col1a1-cre)1Kry, transgene insertion 1, Gerard Karsenty Copyright: This image is from Molyneux SD, J Clin Invest 2010 Sep 1;120(9):3310-25 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:165282
	Caption: Dexamethasone suppression has no effect on Prkar1a^tm1Lsk/Prkar1a^tm1Lsk Tg(Akr1b7-cre)1Anm/0 adrenals (details) Represented Alleles: Prkar1a^tm1Lsk, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, Lawrence S Kirschner Tg(Akr1b7-cre)1Anm, transgene insertion 1, Antoine Martinez Copyright: This image is from Sahut-Barnola I, PLoS Genet 2010;6(6):e1000980, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:161521
	Caption: Morphological defects and progressive hyperplasia in Prkar1a^tm1Lsk/Prkar1a^tm1Lsk Tg(Akr1b7-cre)1Anm/0 adrenals (details) Represented Alleles: Prkar1a^tm1Lsk, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, Lawrence S Kirschner Tg(Akr1b7-cre)1Anm, transgene insertion 1, Antoine Martinez Copyright: This image is from Sahut-Barnola I, PLoS Genet 2010;6(6):e1000980, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:161521
	Caption: Tumors in Prkar1a^tm1Gsm/Prkar1a⁺ mice (details) Represented Alleles: Prkar1a^tm1Gsm, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight Copyright: This image is from Veugelers M, Proc Natl Acad Sci U S A 2004 Sep 28;101(39):14222-7. Copyright 2004 National Academy of Sciences, U.S.A. J:93393
	Caption: Prkar1a^tm1Gsm/Prkar1a^tm1Gsm embryos are severely growth-retarded (details) Represented Alleles: Prkar1a^tm1Gsm, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight Copyright: This image is from Amieux PS, J Biol Chem 2002 Jul 26;277(30):27294-304 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:78010
	Caption: Prkar1a^tm1Gsm/Prkar1a^tm1Gsm embryos have deficiencies in cranial and trunk mesenchyme (details) Represented Alleles: Prkar1a^tm1Gsm, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight Copyright: This image is from Amieux PS, J Biol Chem 2002 Jul 26;277(30):27294-304 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:78010
	Caption: Prkar1a^tm1Gsm/Prkar1a^tm1Gsm embryos exhibit aberrant migration of mesodermal cells from the primitive streak at E6.5 (details) Represented Alleles: Prkar1a^tm1Gsm, protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight Copyright: This image is from Amieux PS, J Biol Chem 2002 Jul 26;277(30):27294-304 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:78010

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24