Phenotype Images associated with this Gene

About Help FAQ

Phenotype Images associated with this Gene

Symbol
Name
ID

Npc1
NPC intracellular cholesterol transporter 1
MGI:1097712

Click on thumbnail to view full size image with links to phenotype annotations.
Click on allele symbol for full phenotype details.

	Caption: Loss of Purkinje cells in the cerebellum and presence of foam cells in the liver and spleen of Npc1^tm1Mbjg/Npc1^tm1Mbjg mice (details) Represented Alleles: Npc1^tm1Mbjg, NPC intracellular cholesterol transporter 1; targeted mutation 1, Joseph L Goldstein Copyright: This image is from Xie X, Proc Natl Acad Sci U S A 2011 Sep 13;108(37):15330-5. Copyright 2011 National Academy of Sciences, U.S.A. J:176587
	Caption: Abnormal morphology of Npc1^m1N/Npc1^m1N sperm (details) Represented Alleles: Npc1^m1N, NPC intracellular cholesterol transporter 1; Niemann Pick type C1 NIH Copyright: This image is from Fan J, Mol Reprod Dev 2006 Oct;73(10):1284-91, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:119302
	Caption: Analysis of Npc1^m1N/Npc1^m1N testes indicates partially blocked spermatogenesis (details) Represented Alleles: Npc1^m1N, NPC intracellular cholesterol transporter 1; Niemann Pick type C1 NIH Copyright: This image is from Fan J, Mol Reprod Dev 2006 Oct;73(10):1284-91, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:119302
	Caption: Neurodegenerative changes affecting cerebullar Purkinje cells of Npc1^m1N/Npc1^m1N, Npc2^tm1Plob/Npc2^tm1Plob, and double homozygous mice for Npc1^m1N and Npc2^tm1Plob (details) Represented Alleles: Npc1^m1N, NPC intracellular cholesterol transporter 1; Niemann Pick type C1 NIH Npc2^tm1Plob, NPC intracellular cholesterol transporter 2; targeted mutation 1, Peter Lobel and David Sleat Copyright: This image is from Sleat DE, Proc Natl Acad Sci U S A 2004 Apr 20;101(16):5886-91. Copyright 2004 National Academy of Sciences, U.S.A. J:89617

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24