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Phenotype Images associated with this Gene
Symbol
Name
ID 		Spg11
SPG11, spatacsin vesicle trafficking associated
MGI:2444989


7 phenotype image(s) for Spg11 alleles
Showing image(s) 1 to 7
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Click on allele symbol for full phenotype details.

Caption: Spastic and ataxic gait in Spg11Gt(EUCE0085f05)Hmgu/Spg11Gt(EUCE0085f05)Hmgu mice (details)
Represented Alleles:
Spg11Gt(EUCE0085f05)Hmgu, SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH
Copyright: This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803
Caption: Severe neuron loss in the motor cortex and the cerebellum of Spg11Gt(EUCE0085f05)Hmgu/Spg11Gt(EUCE0085f05)Hmgu mice (details)
Represented Alleles:
Spg11Gt(EUCE0085f05)Hmgu, SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH
Copyright: This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803
Caption: Accumulation of autofluoerscent material and activation of astrocytes in different regions of the central nervous system of Spg11Gt(EUCE0085f05)Hmgu/Spg11Gt(EUCE0085f05)Hmgu mice (details)
Represented Alleles:
Spg11Gt(EUCE0085f05)Hmgu, SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH
Copyright: This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803
Caption: Purkinje cells in Spg11Gt(EUCE0085f05)Hmgu/Spg11Gt(EUCE0085f05)Hmgu mice accumulate abnormal autolysosomes (details)
Represented Alleles:
Spg11Gt(EUCE0085f05)Hmgu, SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH
Copyright: This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803
Caption: Regeneration of lysosomes in Spg11Gt(EUCE0085f05)Hmgu/Spg11Gt(EUCE0085f05)Hmgu MEFs is decreased (details)
Represented Alleles:
Spg11Gt(EUCE0085f05)Hmgu, SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH
Copyright: This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803
Caption: Reduced lysosome numbers in Purkinje cells of Spg11Gt(EUCE0085f05)Hmgu/Spg11Gt(EUCE0085f05)Hmgu mice are consistent with impaired autophagic lysosome reformation (details)
Represented Alleles:
Spg11Gt(EUCE0085f05)Hmgu, SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH
Copyright: This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803
Caption: Autolysosomes and lipofuscin-like material in different brain regions of Spg11Gt(EUCE0085f05)Hmgu/Spg11Gt(EUCE0085f05)Hmgu mice (details)
Represented Alleles:
Spg11Gt(EUCE0085f05)Hmgu, SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH
Copyright: This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory