Phenotype Images associated with this Gene

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Phenotype Images associated with this Gene

Symbol
Name
ID

Apc
APC, WNT signaling pathway regulator
MGI:88039

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Click on allele symbol for full phenotype details.

	Caption: Enhanced intestinal tumorigenesis in Apc^Min/Apc⁺ Mir10a^tm1.1Ahl/Mir10a^tm1.1Ahl mice (details) Represented Alleles: Apc^Min, APC, WNT signaling pathway regulator; multiple intestinal neoplasia Mir10a^tm1.1Ahl, microRNA 10a; targeted mutation 1.1, Anders Lund Copyright: This image is from Stadthagen G, PLoS Genet 2013 Oct;9(10):e1003913, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:205135
	Caption: Rab25^tm1Jrgo/Rab25^tm1Jrgo Apc^Min/Apc⁺ mice exhibit increased intestinal adenoma formation compared to Apc^Min/Apc⁺ mice (details) Represented Alleles: Apc^Min, APC, WNT signaling pathway regulator; multiple intestinal neoplasia Rab25^tm1Jrgo, RAB25, member RAS oncogene family; targeted mutation 1, James R Goldenring Copyright: This image is from Nam KT, J Clin Invest 2010 Mar;120(3):840-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158733
	Caption: Rab25^tm1Jrgo/Rab25^tm1Jrgo Apc^Min/Apc⁺ mice exhibit increased colon adenoma formation compared to Apc^Min/Apc⁺ mice (details) Represented Alleles: Apc^Min, APC, WNT signaling pathway regulator; multiple intestinal neoplasia Rab25^tm1Jrgo, RAB25, member RAS oncogene family; targeted mutation 1, James R Goldenring Copyright: This image is from Nam KT, J Clin Invest 2010 Mar;120(3):840-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158733
	Caption: Anterior head defects during embryonic development in Apc^Min/Apc^tm1Tno embryos and rescue of head defects by Ctnnb1^tm4.1Wbm/Ctnnb1⁺ (details) Represented Alleles: Apc^Min, APC, WNT signaling pathway regulator; multiple intestinal neoplasia Apc^tm1Tno, APC, WNT signaling pathway regulator; targeted mutation 1, Tetsuo Noda Ctnnb1^tm4.1Wbm, catenin beta 1; targeted mutation 4.1, Walter Birchmeier Copyright: This image is from Buchert M, PLoS Genet 2010 Jan;6(1):e1000816, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:156864
	Caption: Liver zonation is affected in hypomorphic Apc^tm1Tno/Apc^tm1Tno mutant mice (details) Represented Alleles: Apc^tm1Tno, APC, WNT signaling pathway regulator; targeted mutation 1, Tetsuo Noda Copyright: This image is from Buchert M, PLoS Genet 2010 Jan;6(1):e1000816, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:156864
	Caption: Abnormal head structure development in Apc⁺/Apc^tm1Tno embryos and rescue by Ctnnb1^tm4.1Wbm/Ctnnb1⁺ (details) Represented Alleles: Apc^Min, APC, WNT signaling pathway regulator; multiple intestinal neoplasia Apc^tm1Tno, APC, WNT signaling pathway regulator; targeted mutation 1, Tetsuo Noda Ctnnb1^tm4.1Wbm, catenin beta 1; targeted mutation 4.1, Walter Birchmeier Copyright: This image is from Buchert M, PLoS Genet 2010 Jan;6(1):e1000816, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:156864
	Caption: Mammary adenocarcinomas from Apc^tm2Rfo/Apc⁺ mice (details) Represented Alleles: Apc^tm2Rfo, APC, WNT signaling pathway regulator; targeted mutation 2, Riccardo Fodde Copyright: This image is from Gaspar C, PLoS Genet 2009 Jul;5(7):e1000547, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151494
	Caption: Mammary tumors and pulmonary metastases from Apc^tm2Rfo/Apc⁺ mice show typical mammary glandular architecture and squamous differentiation (details) Represented Alleles: Apc^tm2Rfo, APC, WNT signaling pathway regulator; targeted mutation 2, Riccardo Fodde Copyright: This image is from Gaspar C, PLoS Genet 2009 Jul;5(7):e1000547, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151494
	Caption: Phenotypic analysis of the compound in cis Apc^tm2Rfo/Apc⁺ Smad4^E6sad/Smad4⁺ mouse model (details) Represented Alleles: Apc^tm2Rfo, APC, WNT signaling pathway regulator; targeted mutation 2, Riccardo Fodde Smad4^E6sad, SMAD family member 4; Exon 6 splice acceptor deletion Copyright: This image is from Gaspar C, PLoS Genet 2009 Jul;5(7):e1000547, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151494
	Caption: Skeletogenesis is severely impaired in Apc^tm1Rsmi/Apc^tm1Rsmi Tg(Col2a1-cre)1Rsjo/0 mice (details) Represented Alleles: Apc^tm1Rsmi, APC, WNT signaling pathway regulator; targeted mutation 1, Ron Smits Tg(Col2a1-cre)1Rsjo, transgene insertion 1, Randall S Johnson Copyright: This image is from Miclea RL, BMC Dev Biol 2009;9():26, an open-access article, licensee BioMed Central Ltd. J:149225

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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