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Phenotype Images associated with this Gene
Symbol
Name
ID 		Ptk2
PTK2 protein tyrosine kinase 2
MGI:95481


6 phenotype image(s) for Ptk2 alleles
Showing image(s) 1 to 6
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Click on allele symbol for full phenotype details.

Caption: Suppressed mammary tumor growth in Ptk2tm3.1Guan/Ptk2tm3.1Guan Tg(MMTV-PyVT)634Mul/0 mice (details)
Represented Alleles:
Ptk2tm3.1Guan, PTK2 protein tyrosine kinase 2; targeted mutation 3.1, Jun-Lin Guan
Tg(MMTV-PyVT)634Mul, transgene insertion 634, William Muller
Copyright: This image is from Fan H, J Biol Chem 2013 Feb 1;288(5):3322-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:195658
Caption: Embryonic lethality and vascular defects in Ptk2tm1.1Itl/Ptk2tm1.1Itl embryos (details)
Represented Alleles:
Ptk2tm1.1Itl, PTK2 protein tyrosine kinase 2; targeted mutation 1.1, inGenious Targeting Laboratory
Copyright: This image is from Lim ST, J Biol Chem 2010 Jul 9;285(28):21526-36 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165360
Caption: Defective endothelial cell patterning within Ptk2tm1.1Itl/Ptk2tm1.1Itl embryos (details)
Represented Alleles:
Ptk2tm1.1Itl, PTK2 protein tyrosine kinase 2; targeted mutation 1.1, inGenious Targeting Laboratory
Copyright: This image is from Lim ST, J Biol Chem 2010 Jul 9;285(28):21526-36 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165360
Caption: Primary Ptk2tm1.1Itl/Ptk2tm1.1Itl MEFs exhibit increased focal adhesion formation and lack persistence of cell movement (details)
Represented Alleles:
Ptk2tm1.1Itl, PTK2 protein tyrosine kinase 2; targeted mutation 1.1, inGenious Targeting Laboratory
Copyright: This image is from Lim ST, J Biol Chem 2010 Jul 9;285(28):21526-36 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165360
Caption: Hemorrhages, edemas, abnormal heart, lung, liver and limb development, and delayed artery formation and vascular remodeling defects in Ptk2tm1Heen/Ptk2tm1Heen embryos (details)
Represented Alleles:
Ptk2tm1Heen, PTK2 protein tyrosine kinase 2; targeted mutation 1, Herve Enslen
Copyright: This image is from Corsi JM, J Biol Chem 2009 Dec 11;284(50):34769-76 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:157804
Caption: Delayed spreading and abnormal lamellipodia in Ptk2tm1Heen/Ptk2tm1Heen fibroblasts and endothelial cells (details)
Represented Alleles:
Ptk2tm1Heen, PTK2 protein tyrosine kinase 2; targeted mutation 1, Herve Enslen
Copyright: This image is from Corsi JM, J Biol Chem 2009 Dec 11;284(50):34769-76 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:157804
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory