Phenotype Images associated with this Gene

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Phenotype Images associated with this Gene

Symbol
Name
ID

Hexb
hexosaminidase B
MGI:96074

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Click on allele symbol for full phenotype details.

	Caption: Localized glycolipid storage and microgliosis in Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 mice (details) Represented Alleles: Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa, transgene insertion, Timothy J Sargeant Copyright: This image is from Sargeant TJ, PLoS Genet 2012 Sep;8(9):e1002943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:190450
	Caption: Doxycycline treatment of Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 and Hexb^tm1Rlp/Hexb^tm1Rlp Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 mice induces storage of glycolipids (details) Represented Alleles: Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa, transgene insertion, Timothy J Sargeant Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa, transgene insertion, Timothy J Sargeant Copyright: This image is from Sargeant TJ, PLoS Genet 2012 Sep;8(9):e1002943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:190450
	Caption: Doxycycline treatment of Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 and Hexb^tm1Rlp/Hexb^tm1Rlp Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 mice induces neuroinflammation (details) Represented Alleles: Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa, transgene insertion, Timothy J Sargeant Copyright: This image is from Sargeant TJ, PLoS Genet 2012 Sep;8(9):e1002943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:190450
	Caption: Peripheral monocytes/macrophages are seen in the central nervous system of Hexb^tm1Rlp/Hexb^tm1Rlp mice (details) Represented Alleles: Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Copyright: This image is from Wu YP, Proc Natl Acad Sci U S A 2004 Jun 1;101(22):8425-30. Copyright 2004 National Academy of Sciences, U.S.A. J:90687
	Caption: Hexb^tm1Rlp/Hexb^tm1Rlp mice exhibit Sandhoff disease phenotypes that are improved in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice (details) Represented Alleles: Ccl3^tm1Unc, C-C motif chemokine ligand 3; targeted mutation 1, University of North Carolina Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Copyright: This image is from Wu YP, Proc Natl Acad Sci U S A 2004 Jun 1;101(22):8425-30. Copyright 2004 National Academy of Sciences, U.S.A. J:90687
	Caption: Lessened macrophage/microglia associated pathology in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice compared to Hexb^tm1Rlp/Hexb^tm1Rlp mice (details) Represented Alleles: Ccl3^tm1Unc, C-C motif chemokine ligand 3; targeted mutation 1, University of North Carolina Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Copyright: This image is from Wu YP, Proc Natl Acad Sci U S A 2004 Jun 1;101(22):8425-30. Copyright 2004 National Academy of Sciences, U.S.A. J:90687
	Caption: Neuronal apoptosis is reduced in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice compared to Hexb^tm1Rlp/Hexb^tm1Rlp mice (details) Represented Alleles: Ccl3^tm1Unc, C-C motif chemokine ligand 3; targeted mutation 1, University of North Carolina Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Copyright: This image is from Wu YP, Proc Natl Acad Sci U S A 2004 Jun 1;101(22):8425-30. Copyright 2004 National Academy of Sciences, U.S.A. J:90687
	Caption: Hexb^tm1Rlp/Hexb^tm1Rlp B4galnt1^tm1Rlp/B4galnt1^tm1Rlp mice have a hunched posture and are disheveled compared to B4galnt1^tm1Rlp/B4galnt1^tm1Rlp mice (details) Represented Alleles: B4galnt1^tm1Rlp, beta-1,4-N-acetyl-galactosaminyl transferase 1; targeted mutation 1, Richard L Proia Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Copyright: This image is from Liu Y, J Clin Invest 1999 Feb;103(4):497-505 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53080
	Caption: Spinal cord pathology comparison of Hexb^tm1Rlp/Hexb^tm1Rlp B4galnt1^tm1Rlp/B4galnt1^tm1Rlp and Hexb^tm1Rlp/Hexb^tm1Rlp mice (details) Represented Alleles: B4galnt1^tm1Rlp, beta-1,4-N-acetyl-galactosaminyl transferase 1; targeted mutation 1, Richard L Proia Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Copyright: This image is from Liu Y, J Clin Invest 1999 Feb;103(4):497-505 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53080
	Caption: Purkinje cell degeneration in Hexb^tm1Rlp/Hexb^tm1Rlp B4galnt1^tm1Rlp/B4galnt1^tm1Rlp mice (details) Represented Alleles: B4galnt1^tm1Rlp, beta-1,4-N-acetyl-galactosaminyl transferase 1; targeted mutation 1, Richard L Proia Hexb^tm1Rlp, hexosaminidase B; targeted mutation 1, Richard L Proia Copyright: This image is from Liu Y, J Clin Invest 1999 Feb;103(4):497-505 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53080

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