Phenotype Images associated with this Gene

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Phenotype Images associated with this Gene

Symbol
Name
ID

Ldlr
low density lipoprotein receptor
MGI:96765

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Click on allele symbol for full phenotype details.

	Caption: Atherosclerosis lesion area is increased in Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice and TO901317 treatment reduces these lesions (details) Represented Alleles: Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Nr1h3^tm1.1Djm, nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, David J Mangelsdorf Speer6-ps1^{Tg(Alb-cre)21Mgn}, spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson Copyright: This image is from Zhang Y, J Clin Invest 2012 May 1;122(5):1688-99 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:184536
	Caption: Increase in macrophage content in Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 aortic root (details) Represented Alleles: Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Nr1h3^tm1.1Djm, nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, David J Mangelsdorf Speer6-ps1^{Tg(Alb-cre)21Mgn}, spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson Copyright: This image is from Zhang Y, J Clin Invest 2012 May 1;122(5):1688-99 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:184536
	Caption: Adiposity in Ldlr^tm1Her/Ldlr^tm1Her and Scd1^ab-2J/Scd1^ab-2J Ldlr^tm1Her/Ldlr^tm1Her mice (details) Represented Alleles: Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Scd1^ab-2J, stearoyl-Coenzyme A desaturase 1; asebia 2 Jackson Copyright: This image is from MacDonald ML, J Lipid Res 2008 Jan;49(1):217-29 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:130278
	Caption: Hepatic lipids in Ldlr^tm1Her/Ldlr^tm1Her and Scd1^ab-2J/Scd1^ab-2J Ldlr^tm1Her/Ldlr^tm1Her mice (details) Represented Alleles: Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Scd1^ab-2J, stearoyl-Coenzyme A desaturase 1; asebia 2 Jackson Copyright: This image is from MacDonald ML, J Lipid Res 2008 Jan;49(1):217-29 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:130278
	Caption: Phenotype of aortic arch atherosclerotic lesions in Tbx21^tm1Glm/Tbx21^tm1Glm Ldlr^tm1Her/Ldlr^tm1Her and Ldlr^tm1Her/Ldlr^tm1Her mice (details) Represented Alleles: Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Tbx21^tm1Glm, T-box 21; targeted mutation 1, Laurie H Glimcher Copyright: This image is from Buono C, Proc Natl Acad Sci U S A 2005 Feb 1;102(5):1596-601. Copyright 2005 National Academy of Sciences, U.S.A. J:96110
	Caption: Cutaneous xanthomatosis and alopecia in Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her mice (details) Represented Alleles: Apoe^tm1Unc, apolipoprotein E; targeted mutation 1, University of North Carolina Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Soat1^tm1Ishi, sterol O-acyltransferase 1; targeted mutation 1, Shun Ishibashi Copyright: This image is from Yagyu H, J Biol Chem 2000 Jul 14;275(28):21324-30 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63468
	Caption: Histopathology of cutaneous lesions developed in Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her mice fed high fat diets (details) Represented Alleles: Apoe^tm1Unc, apolipoprotein E; targeted mutation 1, University of North Carolina Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Soat1^tm1Ishi, sterol O-acyltransferase 1; targeted mutation 1, Shun Ishibashi Copyright: This image is from Yagyu H, J Biol Chem 2000 Jul 14;275(28):21324-30 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63468
	Caption: Soat1^tm1Far/Soat1^tm1Far Ldlr^tm1Her/Ldlr^tm1Her mice fed an atherogenic diet for 2 months display severe xanthomatosis (details) Represented Alleles: Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Soat1^tm1Far, sterol O-acyltransferase 1; targeted mutation 1, Bob Farese Copyright: This image is from Accad M, J Clin Invest 2000 Mar;105(6):711-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:61147
	Caption: Neutral lipid-poor atherosclerotic lesions in Apoe^tm1Unc/Apoe^tm1Unc Soat1^tm1Far/Soat1^tm1Far and Soat1^tm1Far/Soat1^tm1Far Ldlr^tm1Her/Ldlr^tm1Her mice (details) Represented Alleles: Apoe^tm1Unc, apolipoprotein E; targeted mutation 1, University of North Carolina Ldlr^tm1Her, low density lipoprotein receptor; targeted mutation 1, Joachim Herz Soat1^tm1Far, sterol O-acyltransferase 1; targeted mutation 1, Bob Farese Copyright: This image is from Accad M, J Clin Invest 2000 Mar;105(6):711-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:61147

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