Phenotype Images associated with this Gene

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Phenotype Images associated with this Gene

Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

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Click on allele symbol for full phenotype details.

	Caption: Embryonic lethality in Ptpn11^tm1Ckq/Ptpn11⁺ Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺ mice (details) Represented Alleles: Hprt1^{tm1(CAG-cre)Mnn}, hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Jeffrey R Mann Ptpn11^tm1Ckq, protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Cheng-Kui Qu Copyright: This image is from Xu D, J Exp Med 2011 Sep 26;208(10):1977-88, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:177285
	Caption: Increased spleen weight in Ptpn11^tm1Ckq/Ptpn11⁺ Tg(Mx1-cre)1Cgn/0 mice (details) Represented Alleles: Ptpn11^tm1Ckq, protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Cheng-Kui Qu Tg(Mx1-cre)1Cgn, transgene insertion 1, University of Cologne Copyright: This image is from Xu D, J Exp Med 2011 Sep 26;208(10):1977-88, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:177285
	Caption: Ptpn11^tm4.2Bgn/Ptpn11⁺ mice demonstrate phenotypic abnormalities similar to those in human Leopard syndrome (LS) (details) Represented Alleles: Ptpn11^tm4.2Bgn, protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel Copyright: This image is from Marin TM, J Clin Invest 2011 Mar 1;121(3):1026-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172033
	Caption: Ptpn11^tm4.2Bgn/Ptpn11⁺ mice have pathological cardiac hypertrophy (details) Represented Alleles: Ptpn11^tm4.2Bgn, protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel Copyright: This image is from Marin TM, J Clin Invest 2011 Mar 1;121(3):1026-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172033
	Caption: Myofiber disarray, enlarged nuclei, and fibrosis in 52-week-old Ptpn11^tm4.2Bgn/Ptpn11⁺ hearts (details) Represented Alleles: Ptpn11^tm4.2Bgn, protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel Copyright: This image is from Marin TM, J Clin Invest 2011 Mar 1;121(3):1026-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172033
	Caption: Ptpn11^tm4.2Bgn/Ptpn11⁺ mice have hypertrophic cardiomyopathy that progresses to chamber dilation (details) Represented Alleles: Ptpn11^tm4.2Bgn, protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel Copyright: This image is from Marin TM, J Clin Invest 2011 Mar 1;121(3):1026-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172033
	Caption: Defects in the skin, lung and intestine of Egfr^wa2/Egfr^wa2 Ptpn11^tm1Paw/⁺ mice (details) Represented Alleles: Egfr^wa2, epidermal growth factor receptor; waved 2 Ptpn11^tm1Paw, protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Anthony Pawson Copyright: This image is from Qu CK, Proc Natl Acad Sci U S A 1999 Jul 20;96(15):8528-33. Copyright 1999 National Academy of Sciences, U.S.A. J:75413

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