Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:44025 Manenti G, et al., Pas1 is a common lung cancer susceptibility locus in three mouse strains. Mamm Genome. 1997;8(11):801-4
• ID
  MGI:1194761

Genes

Gene	Assay Type	Description
D6Mit8	reported elsewhere
D6Mit32	reported elsewhere
D6Mit291	reported elsewhere
D6Mit198	reported elsewhere
D6Mit157	reported elsewhere
D6Mit201	reported elsewhere
D6Int1	reported elsewhere
Kras	PCR amplified length variant	FK2i, RK2i
Pas18	visible phenotype

Notes

• Experiment
  The authors mapped the Pas1 lung cancer susceptibility locus using 193 female (BALB/cJ x C3H/HeJ)F2 mice induced with i.p. injections of urethane. SWR/J, BALB/cJ and C3H/HeJ strains are susceptible, intermediately susceptible and resistant to lung tumorigenesis, respectively. F2 mice were analyzed with following loci: D6Mit8, D6Mit32, D6Mit291, D6Mit198, D6Mit157, Kras, D6Mit201, and D6Int1. A peak LOD score of 28.4 was associated with Kras.
  
  12.16.2015 Curator Note: Because Pas1 was orginally mapped in J:17778, in 1997 using an (C57BL/6J x A/J)F2 intercross, which differs from the cross used here, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Pas18 .
  
  Researchers attempted to confirm the mapping in (BALB/cJ x SWR/J)F2 animals, but no polymorphism could be found at the Kras2 locus, suggesting these strains may share the same Pas1 allele (additionally, no association between Pas1 and D6Mit114, D6Mit294 or D6Mit115 was found).