Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  4
• Reference
  J:43992 Mock BA, et al., The plasmacytoma resistance gene, Pctr2, delays the onset of tumorigenesis and resides in the telomeric region of chromosome 4. Blood. 1997 Nov 15;90(10):4092-8
• ID
  MGI:1195995

Genes

Gene	Assay Type	Description
Xmv8	PCR amplified length variant	SB1, Xmv8SB2
Xmv44	PCR amplified length variant	SB1, Xmv44SB5
Pctr2	resistance/susceptibility
Nppa	reported elsewhere
Fv1	visible phenotype
D4Mit190	reported elsewhere

Notes

• Experiment
  BALB/cAnPt mice are susceptibile to plasmacytomas whereas DBA/J mice are resistant. A series of congenic strains recombinant for regions of mouse Chromosome 4 in the vicinity of the Pctr2 locus was derived by backcrossing alleles from DBA/2 mice onto the susceptible BALB/cAnPt background. These strains were typed for their tumor susceptibility/resistance phenotypes and then allelotyped for 10 genes and 49 random markers. The smallest region of overlap between the resistant and susceptible strains suggested two posible locations for the Pctr2 gene on mouse Chromosome 4: (1) within the interval between Xmv8 and Xmv44 or (2) in the 1- to 2-cM interval between Nppa and D4Mit190.