Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:46300 Simpson VJ, et al., Identification of a genetic region in mice that specifies sensitivity to propofol. Anesthesiology. 1998 Feb;88(2):379-89
• ID
  MGI:1203565

Genes

Gene	Assay Type
Lorp1	visible phenotype
Tyr	reported elsewhere

Notes

• Experiment
  Selectively bred long sleep (LS) and short sleep (SS) mice were used to generate 164 F2 intercross and 25 recombinant inbred progeny to localize a quantitative trait locus (QTL) associated with Propofol nuerosensitivity. LS mice exhibit a longer loss of the righting reflex when treated with the drug than do SS mice. A single QTL, called Lorp1, was found in a 2.7 cM interval on mouse Chromosome 7, tightly linked to Tyr. This locus accounted for 80% of the genetic variance between LS and SS RI strains.