Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  2
• Reference
  J:47974 Johnson KR, et al., A new spontaneous mouse mutation of Hoxd13 with a polyalanine expansion and phenotype similar to human synpolydactyly. Hum Mol Genet. 1998 Jun;7(6):1033-8
• ID
  MGI:1270167

Genes

Gene	Allele	Assay Type
D2Mit124		PCR amplified length variant
D2Mit245		PCR amplified length variant
D2Mit37		PCR amplified length variant
Hoxd13	Hoxd13^spdh	visible phenotype
D2Mit126		PCR amplified length variant
D2Mit300		PCR amplified length variant
D2Mit17		PCR amplified length variant

Notes

• Experiment
  A mouse mutation designated spdh for synpolydactyly homolog was mapped in 100 meioses from the following intercross (B6C3Fe a/a-Csfm^op x CAST/Ei)F1 x (B6C3Fe a/a-Csfm^op x CAST/Ei)F1. The spdh mutation mapped with the loci on mouse Chromosome 2 with the followingorder of loci: D2Mit124 - 2.0 cM - D2Mit245 - 3.0 cM - D2Mit37 - Hoxd13^spdh - 2.0 cM - D2Mit126 - 2.0 cM - D2Mit300 - 5.0 cM - D2Mit17. The spdh mutation which arose on the C3HeB/FeJFe chromosome was identified as a 21bp duplication within the Hoxd13 locus. D2Mit37 is contained within the Hoxd cluster and did not recombine with the spdh mutant phenotype.