Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:48305 Mock BA, et al., Multigenic control of skin tumor susceptibility in SENCARA/Pt mice. Carcinogenesis. 1998 Jun;19(6):1109-15
• ID
  MGI:1277257

Genes

Gene	Assay Type
D5Mit259	PCR amplified length variant
Skts4	resistance/susceptibility
D5Mit188	PCR amplified length variant
D5Mit369	PCR amplified length variant

Notes

• Experiment
  Outbred SENCARA/Pt mice are susceptible to the development of skin papillomas whereas BALB/cAnPt mice are highly resistant. In an attempt to find loci contributing to the susceptibile/resistant phenotype, 81 N2 progeny from a (BALB/cAnPt x SENCARA/Pt)F1 x SENCARA/Pt backcross were analyzed in a genome wide scan using 89 microsatellite markers. Using quantitative trait analysis, Skts4 was mapped to mouse Chromosome 5 in a 21 cM interval between D5Mit259 and D5Mit369 (peak = D5Mit188, LOD of 3.75). Suggestive associations were also found with markers on Chromosomes 9, 11 and 12.