Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  18
• Reference
  J:48957 Leiter EH, et al., NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes. 1998 Aug;47(8):1287-95
• ID
  MGI:1278358

Genes

Gene	Assay Type
D18Mit60	PCR amplified length variant
Nidd2	visible phenotype

Notes

• Experiment
  NON/LtHl inbred mice were selected for impaired glucose tolerance and NZO/Hl inbreds were selected for polygenic obesity, respectively. Their male F1 progeny consistently developed NIDDM (non-insulin-dependent diabetes mellitus).
  
  A total of 193 (NZO/Hlx NON/LtHl)F2 and 201 (NON/LtHl x NZO/Hl)F2 mice were informative in identifying NIDDM susceptibility trait loci.
  
  Nidd2 was contributed by the NON/LtHl background and mapped to an interval of mouse Chromosome 18 that contained the marker D18Mit60 with a peak LOD of approximately 5.0.