Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:48957 Leiter EH, et al., NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes. 1998 Aug;47(8):1287-95
• ID
  MGI:1278359

Genes

Gene	Assay Type
Nidd3	visible phenotype
D11Mit41	PCR amplified length variant
D11Mit261	PCR amplified length variant

Notes

• Experiment
  NON/LtHl inbred mice were selected for impaired glucose tolerance and NZO/Hl inbreds were selected for polygenic obesity, respectively. Their male F1 progeny consistently developed NIDDM (non-insulin-dependent diabetes mellitus).
  
  A total of 193 (NZO/Hlx NON/LtHl)F2 and 201 (NON/LtHl x NZO/Hl)F2 mice were informative in identifying NIDDM susceptibility trait loci.
  
  Nidd3 was contributed by the NON/LtHl background and mapped to an interval of mouse Chromosome 11 that contained a peak at marker D11Mit261 (LOD 8.9) and a peak at marker D11Mit41 (LOD 11.1).