Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:40638 Vyse TJ, et al., Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice. J Immunol. 1997 Jun 1;158(11):5566-74
• ID
  MGI:1278424

Genes

Gene	Assay Type
D1Mit111	SSLP
Nba2	visible phenotype
D1Mit148	SSLP
Nba9	visible phenotype
Crp	SSLP

Notes

• Experiment
  Authors localized the Nba2 quantitative trait locus (QTL) associated with lupus nephritis and the production of multiple autoantibody specificities implicated in the pathogenesis of the disorder. This locus was mapped with the stongest linkage to mouse Chromosome 1, using 82 (NZB/BlNJ x SM/J)F1 x NZW/LacJ. Peak linkage was observed at D1Mit48 and D1Mit111 with p<0.002 at 92cM.
  
  Using 133 (B6.H2^z x NZB)F1 x NZB backcross mice the authors map a QTL to a similar postion on Chromosome 1, peak linkage with Crp, p<0.001 at 94cM. A genome wide screen of the B6 backcross was completed with a total of 80 SSLP markers
  
  07.15.2015 Curator Note: Because two different crosses were used in this study we consider each a separate mapping experiment and have named the QTL identified in the B6 cross Nba9.
  
  When the data from both crosses was combined peak linkage was apparent between 94 and 96cM.. The 95% confidence interval is between 92 -97cM.
  
  Both Nba2 and Nba9 were linked (or showed a trend for linkage) with elevated serum levels of multiple autoantibodies, hypergammaglobulinemia and IgG1, IgG2a and/or IgG3 levels in each backcross.