Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  14
• Reference
  J:47545 Bureau JF, et al., Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse. Genetics. 1998 Apr;148(4):1941-9
• ID
  MGI:1289500

Genes

Gene	Assay Type
D14Mit54	PCR amplified length variant
Tmevd3	resistance/susceptibility
Tmevd4	resistance/susceptibility

Notes

• Experiment
  108 (DBA/2J x B10.D2)F2 mice were subjected to quantitative trait analysis (QTL) for chronic demyelinating disease caused by Theiler's murine encephalomyelitis (Tmevd3). DBA/2J mice are susceptibile to the disorder, B10.D2 mice are resistant. A significant association of the demyelinating phenotype with Chromosome 14 marker D14Mit54 was indicated. This QTL region was large and covered approximately 54 cMs. The authors observed two peaks within the QTL and suggested that two loci may be involved in the phenotype. This second locus is designated as Tmevd4.