Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:40532 Buck KJ, et al., Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci. 1997 May 15;17(10):3946-55
• ID
  MGI:1309648

Genes

Gene	Assay Type
Alcw2	visible phenotype
Tyrp1	reported elsewhere

Notes

• Experiment
  Authors localized quantitative trait loci involved with alcohol dependence/genetic predisposition to acute alcohol withdrawal in mice. BXD (C57BL/6J x DBA/2J) strains, B6D2 F2 animals, and HAW (high alcohol withdrawal) LAW (low alcohol withdrawal) animals was used to identify a QTL, Alcw2 (LOD = 5.6). This locus is in proximity to Tyrp1 on mouse Chromosome 4 approximately 40 cM from the centromere and accounts for about 6% of the total phenotypic variance in alcohol withdrawal between D2 and B6 strains (26% of the genetic variance).