Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:44650 Gershenfeld HK, et al., Mapping quantitative trait loci for fear-like behaviors in mice. Genomics. 1997 Nov 15;46(1):1-8
• ID
  MGI:1316451

Genes

Gene	Assay Type
Exq1	visible phenotype
D10Mit237	PCR amplified length variant

Notes

• Experiment
  Parental strains (A/J x C57BL/6J) and their F1 and 518 F2 intercross offspring were assessed for their fear-like behaviors in light-to-dark (LD) transition paradigm behavior tests. Parental strain C57BL/6J exhibits increased light-dark transitions and increased center time in an open field compared to parental strain A/J. Whole genome scan using 114 polymorphic markers indicated the presence of of a linked quantitative trait locus (QTL) on mouse Chromosome 10 near D10Mit237 (LOD = 9.3). Exq1 is associated with LD transitions during the first and third trials (LD1 and LD3). The Exq1 locus was previously shown by these authors to influence both initial and habituated ambulatory and vertical activity (see J:41249).
  
  A suggestive locus mapped to 49 cM on mouse Chromosome X with LOD = 2.84 at DXMit172. This locus is associated with LD transitions during the third LD transition trial (LD3) but not the first or second.