Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:49710 Beamer WG, et al., Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res. 1998 Aug 15;58(16):3694-9
• ID
  MGI:1330468

Genes

Gene	Assay Type
D4Mit232
Gct1	visible phenotype
D4Mit190

Notes

• Experiment
  The authors analyzed the F2 female progeny from four reciprocal F1 x F1 intercrosses [cross A. (SJL x SWR)F1 x (SJL x SWR)F1; cross B. (SJL x SWR)F1 x (SWR x SJL)F1; cross C. (SWR x SJL)F1 x (SJL x SWR)F1; cross D. (SWR x SJL)F1 x (SWR x SJL)F1] for granulosa cell (GC) tumors at 8 weeks of age to identify QTLs. D4Mit232 yielded the highest significance level of association GC tumorigenesis (chi square = 41.18; P<0.0001). The distal boundary of significant association with Gct has not been defined because of insufficient polymorphisms between SWR and SJL for loci distal to D4Mit190. The authors also found that at least one SWR-derived Gct allele is required for tumorigenesis and that this loci behaves like an oncogene with the SWR allele acting in a dominant fashion.