Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:49710 Beamer WG, et al., Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res. 1998 Aug 15;58(16):3694-9
• ID
  MGI:1330470

Genes

Gene	Assay Type
D12Mit172
Gct2	visible phenotype

Notes

• Experiment
  The authors analyzed the F2 female progeny from four reciprocal F1 x F1 intercrosses [cross A. (SJL x SWR)F1 x (SJL x SWR)F1; cross B. (SJL x SWR)F1 x (SWR x SJL)F1; cross C. (SWR x SJL)F1 x (SJL x SWR)F1; cross D. (SWR x SJL)F1 x (SWR x SJL)F1] for granulosa cell (GC) tumors at 8 weeks of age to identify QTLs. D12Mit172 yielded a significant level of association GC tumorigenesis (chi square = 13.16; P<0.0001). The authors suggest that the Gct locus modifies tumor susceptibility but is not required for tumorigenesis.