Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  X
• Reference
  J:49710 Beamer WG, et al., Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res. 1998 Aug 15;58(16):3694-9
• ID
  MGI:1330487

Genes

Gene	Assay Type
DXMit16
Gct4	visible phenotype

Notes

• Experiment
  The authors analyzed three matings for genetic analysis to identify QTLs responsible for tumor susceptibility. 1) F2 female progeny from four reciprocal F1 x F1 intercrosses [cross A. (SJL x SWR)F1 x (SJL x SWR)F1; cross B. (SJL x SWR)F1 x (SWR x SJL)F1;cross C. (SWR x SJL)F1 x (SJL x SWR)F1; cross D. (SWR x SJL)F1 x (SWR x SJL)F1]. 2) The SWR congenic strains [SWR.SJL-X1, SWR.SJL-X2, SWR.SJL-X3, SWR.SJL-X4] containing most of Chromosome X from DXMit55 to DXMit182 and 3)SW x J RI strains. They were ableto identify a SJL derived susceptibility allele on mouse Chromosome X associated with DXMit16. The authors suggest that DXMit16 is not sufficient for tumorigenesis without the SWR susceptibility allele linked to D4Mit232. The authors also identified a parent of origin effect associated with the paternal allele of DXMit16 (chi square = 9.22; P<0.001). Thus females that inherited the SJL allele from the father have higher tumor incidences than those that inherit the allele from their mothers. An interesting candidate gene for Gct4 is the Ar locus which maps less than 1 cM proximal to DXMit16.