Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  6
• Reference
  J:32389 Hochtl J, et al., A novel type of aberrant recombination in immunoglobulin genes and its implications for V-J joining mechanism. Nature. 1983 Mar 17-23;302(5905):260-3
• ID
  MGI:1331711

Genes

Gene	Assay Type	Description
D6Hgz1	direct sequencing	L10 clones, K-41 clones,f-41
Igkj1	direct sequencing	L10 clones, K-41 clones,f-41
Igkj2	reported elsewhere
Igkj3	reported elsewhere
Igkj4	reported elsewhere
Igkj5	reported elsewhere
Igkc	direct sequencing	L10 clones, K-41 clones

Notes

• Experiment
  The authors observed that both D6Hgz1 (authors calls it L10) and Igk-C sequences are deleted in tumor RPC20, suggesting that there is physial linkage between the two DNA segments. Clones derived from MOPC41 myeloma cells indicate that abberant reciprocalrecombination of the D6Hgz1 and Igk-J1 genes occurs. This recombination merges the 5' -flank of Igk-J1 and the 3' -flank D6Hgz1 (fragment f-41) and the 3' -flank of Igk-J1 with the 5' -flank of D6Hgz1 (fragment K-41). Non-recombinant gene order on mouse Chromosome 6 is reported as: 3' - D6Hgz1 - 5' - Igk-J1 - Igk-J2 - Igk-J3 - Igk-J4 - Igk-J5 - Igk-C.