Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:53356 McIndoe RA, et al., Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2210-4
• ID
  MGI:1333947

Genes

Gene	Assay Type
Cia2	resistance/susceptibility
D2Mit61
Cia4	visible phenotype
Ptgs1
Dpp4
Ssb
Hc

Notes

• Experiment
  The authors performed experiments to localize susceptibility loci for collagen induced arthritis (CIA). F2 crosses between the highly susceptible DBA/1J strain and the highly resistant SWR/J strains were analyzed for the presence of QTLs. A locus, Cia2 on mouse Chromosome 2 had significant evidence of linkage to D2Mit61 (lod score of 6.34). Two-point analysis using BYMARKER showed that the incidence and severity of the CIA phenotype was significantly associated with D2Mit61 (F = 10.5, P<0.0001). Another QTL associated with the age of onset of CIA, Cia4 was also linked to D2Mit61 (lod score of 3.2, F = 15.8 P<0.000001). Candidate genes in this interval include Ptgs1, Dpp4, Ssb and Hc.