Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:53356 McIndoe RA, et al., Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2210-4
• ID
  MGI:1333948

Genes

Gene	Assay Type
Cia3	resistance/susceptibility
D6Mit10
Tnfrsf1a
Cd4
Il5ra
Cd27
Tgfa
Hrh1

Notes

• Experiment
  The authors performed experiments to localize susceptibility loci for collagen induced arthritis (CIA). F2 crosses between the highly susceptible DBA/1J strain and the highly resistant SWR/J strains were analyzed for the presence of QTLs. A locus, Cia3 on mouse Chromosome 6 had significant evidence of linkage to D6Mit10 (lod score of 3.19). Two-point analysis using BYMARKER showed that the incidence and severity of the CIA phenotype was significantly associated with D6Mit10 (F = 8.9, P<0.00045). Candidate genes in this interval include Tnfrsf1a, Cd4, Il5ra, Tnfrsf7, Tgfa and Hrh1.