Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:51522 Poltorak A, et al., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998 Dec 11;282(5396):2085-8
• ID
  MGI:1335989

Genes

Gene	Assay Type
Pappa	overlapping clones
Tlr4	overlapping clones
D4Mit178	overlapping clones

Notes

• Experiment
  Detailed physical and genetic mapping of the Lps region of mouse Chromosome 4 is reported in J:50273, Poltorak A; et al. Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Molecules Dis 1998 SEP 15;24(17):340-355. The authors here reported a subset of those mapping data showing a physical BAC order of Pappa - Tlr4 - D4Mit178. There were 4 recombinants between Lps and Pappa in a total of 1600 meioses and 0 recombinants between Lps and D4Mit178 in 2093 meioses. Importantly the authors provide detailed evidence that the mouse Chromosome 4 locus Tlr 4 is responsible for the Lps response in mice.