Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:55364 Lu LM, et al., Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice. Cancer Res. 1999 Jun 1;59(11):2593-5
• ID
  MGI:1338385

Genes

Gene	Assay Type
Bomb1	visible phenotype
D3Mit319
Lef1

Notes

• Experiment
  SL/Kh inbred mice exhibit a high incidence of pre-B lymphomas and an abnormal transient expression of bone marrow pre-B-1 cells, whereas NFS/N mice have a low incidence of spontaneous lymphoma and a low number of bone marrow pre-B-1 cells. F2 and backcross populations of mice derived from crosses betweeb SL/Kh and NFS/N mice were informative in mapping a QTL to mouse Chromosome 3 with a peak LOD (10.7) at marker D3Mit319. A gene within the QTL region that may be a candidate for the Bomb1 phenotype is suggested to be Lef1.