Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:56090 Mu JL, et al., Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/J. J Lipid Res. 1999 Jul;40(7):1328-35
• ID
  MGI:1340600

Genes

Gene	Assay Type
D12Mit182
D12Mit169
D12Mit269
D12Mit49
Ath6	visible phenotype
D12Mit13
D12Mit185
D12Mit221
Adam17	reported elsewhere
Sdc1	reported elsewhere
Apob	reported elsewhere

Notes

• Experiment
  Mice from the inbred strain C57BLKS/J (BKS) show increased susceptibility to diabetes and atherosclerosis compared to C57BL/6J mice. The authors carried out a cross between the C57BL/6J-db/db and BKS mice. F1 heterozygous for the db mutation were mated and F2 db/db progeny were tested for fatty acid lesion streaks in the aorta. A marker order and distance was calculated based on the 99 mice in this cross. D12Mit182 - 3 cM - D12Mit169 - 1.5 cM - D12Mit269 - 0.5 cM - D12Mit49 - 4 cM - D12Mit13 - 0.5 cM - D12Mit185 - 4.0 cM - D12Mit221. The authors found that the lesion size was determined by a locus at D12Mit49 with a LOD score of 2.5 and a significant likelihood ratio statistic (LRS) of 11.4. This was confirmed by constructing a congenic strain with BKS alleles in the QTL region on a C57BL/6 genetic background. The lesions of the congenic strains were significantly larger than those of C57BL/6J but not significantly different from that of the BKS strain. The authors have named this locus Ath6. Ath6 was estimated to account for 25% of the variance of lesion size. Three putative candidate genes have been identified in the region: Apob, Adam17 and Synd1.