Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:31314 Teuscher C, et al., Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3. J Exp Med. 1996 Feb 1;183(2):631-7
• ID
  MGI:1341405

Genes

Gene	Assay Type
Il2
D3Mit21
Fgf2
Aod2	visible phenotype
D3Mit224
D3Mit63
D3Mit133
D3Mit226
D3Mit182
D3Mit227
D3Mit64
D3Mit5
D3Mit6
D3Mit65
D3Mit154

Notes

• Experiment
  Thymectomized progeny, from a backcross of (C57BL/6J x A/J)F1 (susceptible to autoimmune ovarian dysgenesis - AOD) and C57BL/6J (resistant) mice, which exhibited autoimmune oophoritis and ovarian atrophy were subjected to linkage analysis. Using 131 microsatellite loci covering the genome, maximal linkage (P = 0.0007) of a quantitative trait locus associated with phentypic expression of atrophy was found on mouse Chromosome 3 in association with markers D3Mit224, D3Mit63, D3Mit133, D3Mit226, D3Mit182, D3Mit227, D3Mit64, D3Mit5, D3Mit6 and D3Mit65. The authors designated this locus Aod2. Maximum likelihood estimates were carried out on Chromosome 3 by multilocus linkage analysis. A 95% confidence interval was found to be bordered by D3Mit21 (Il2) and D3Mit154. The authors note the presence of Il2, Fgf2, and in particular Idd3 within this region.