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Mapping Data
Experiment
  • Experiment
    TEXT-Genetic Cross
  • Chromosome
    5
  • Reference
    J:54414 Urosevic N, et al., Development and characterization of new flavivirus-resistant mouse strains bearing Flv(r)-like and Flv(mr) alleles from wild or wild-derived mice. J Gen Virol. 1999 Apr;80(Pt 4):897-906
  • ID
    MGI:1342258
Genes
GeneAlleleAssay TypeDescription
D5Mit26
D5Mit158
Oas1b visible phenotype
D5Mit138
Gusb
Notes
  • Experiment
    A single genetic locus Flv, on mouse Chromosome 5, controls virus titres and severity of flavivirus infection in mouse brain. The authors have developed two new flavivirus resistant mouse strains, C3H.M. domesticus-Flvr and C3H.MOLD-Flvmr, that carrynovel resistance alleles Flvr like and Flv,mr> respectively on a genetic background of flavivirus susceptible C3H/HeJ mice. Genome analysis of these strains has revealed a chromosomal region of 9 cM between D5Mit26 and D5Mit138 for the Flvr allele and a 11 cM region between D5Mit158 and Gus-s for the Flvmr allele that are derived from resistant donor mice. These new congenic strains represent new animal models of flavivirus resistance conferred by these novel resistance alleles.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory