Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  5
• Reference
  J:54414 Urosevic N, et al., Development and characterization of new flavivirus-resistant mouse strains bearing Flv(r)-like and Flv(mr) alleles from wild or wild-derived mice. J Gen Virol. 1999 Apr;80(Pt 4):897-906
• ID
  MGI:1342258

Genes

Gene	Assay Type
D5Mit26
D5Mit158
Oas1b	visible phenotype
D5Mit138
Gusb

Notes

• Experiment
  A single genetic locus Flv, on mouse Chromosome 5, controls virus titres and severity of flavivirus infection in mouse brain. The authors have developed two new flavivirus resistant mouse strains, C3H.M. domesticus-Flv^r and C3H.MOLD-Flv^mr, that carrynovel resistance alleles Flv^r like and Flv,mr> respectively on a genetic background of flavivirus susceptible C3H/HeJ mice. Genome analysis of these strains has revealed a chromosomal region of 9 cM between D5Mit26 and D5Mit138 for the Flv^r allele and a 11 cM region between D5Mit158 and Gus-s for the Flv^mr allele that are derived from resistant donor mice. These new congenic strains represent new animal models of flavivirus resistance conferred by these novel resistance alleles.