Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:54925 Gershenfeld HK, et al., Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice. J Neurosci. 1999 May 15;19(10):3731-8
• ID
  MGI:1343867

Genes

Gene	Assay Type
D4Mit68
Bis1	visible phenotype

Notes

• Experiment
  The authors examined the gentic basis of differences in seizure behaviour using a GABAa receptor agoinst beta CCM (methyl beta-carboline-3 carboxylate). A/J mice are more susceptible to beta-CCM induced myoclonic seizures than C57BL/6J mice in both latency to seizure and proportion of tested mice that seized. The previously identified Bis1 QTL was confirmed in a subsequent backcross population (n = 223), D4Mit68 on distal Chromosome 4 is associated with seizure susceptibility (chi square = 10.3; p<0.0012; n = 217) and seizure latency. A LOD score = 2.88 was assigned to this locus and it accounted for 6-9% of the phenotypic variance for this seizure trait. The best-fitting logistic regression model suggests that the C57BL/6J allele at the D4Mit68 locus increased the likelihood of resistance to seizures at 23 fold. Candidate genes in this region include Htr1da, Htr1db and Slc9a1.