Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:56029 Havelkova H, et al., T-cell proliferative response is controlled by loci Tria4 and Tria5 on mouse chromosomes 7 and 9. Mamm Genome. 1999 Jul;10(7):670-4
• ID
  MGI:1343991

Genes

Gene	Assay Type
Tria4	visible phenotype
D7Mit32a

Notes

• Experiment
  Lymphocytes of mouse strain BALB/cHeA and STS/A differ in their response to the CD3 antibody. BALB/c lymphocytes are intermediate responders while STS lymphocytes do not respond to this stimulus. The authors used recombinat congenic strains of BALB/c - c-STS/Dem (CcS/Dem) series to examine the genetic basis of proliferative response to anti-CD3. Proliferative response to anti-CD3 was examined in 170 (CcS-9 x CcS-11)F2 hybrids. CcS-9 was a high responder strain while CcS-11 is a low responder strain. Statistical evaluation revealed linkage of rsponse to lower doses (0.375 ug/ml) of CD3 mAbb to the marker D7Mit32 (corrected P = 0.038). This data indicated the presence of a locus Tria4 on the central part of Chromosome 7 on an STS-derived segment of the strain CcS-11. No effect of age or sex was found. Putative candidate genes in this region include Pmv31, Emv23, Tlag1 and Emv32.