Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:53978 Southard-Smith EM, et al., The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. Genome Res. 1999 Mar;9(3):215-25
• ID
  MGI:1344468

Genes

Gene	Assay Type
D10Mit178	PCR amplified length variant
mwfh	visible phenotype
Kitl	reported elsewhere

Notes

• Experiment
  A phenotypic trait of the Sox^Dom mutation in mice is hypopigmentation. Analysis of congenic lines derived on either a C57BL/6JLe or C3HeB/FeJLe-a/a background indicate that the degree of spotting (hypopigmentation) varies between the congenics.
  
  A search for modifer loci effecting the degree of hypopigmentation (white forelock) was initiated in genetic crosses involving the Sox^Dom congenics with B6C3F1/J mice. The results indicated that a modifier locus named mwfh (modifier of white forelock hypopigmentation) showed significant linkage with Chromosome 10 microsatellite marker D10Mit178 at 59 cM (LOD=5.63). Sox^Dom/+ F2 animals homozygous for C3HeB/FeJLe-derived alleles at mwfh exhibit increased incidence of white forelock. This locus appears to exhibit recessive inheritance with reduced penetrance. Mwfh maps to the same region as a modifier locus that effects hypopigmentation in Ednrb mice, however the authors could not ascertain whether the two modifiers were identical. A potential candidate gene for mwfh is Kitl(57 cM).