Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  6
• Reference
  J:57286 Idris AH, et al., Close genetic linkage of Chok with the NKC-linked loci Cd94, Ly49, and Cmv1 on mouse chromosome 6. Immunogenetics. 1999 Sep;49(10):906-8
• ID
  MGI:1344932

Genes

Gene	Allele	Assay Type
Klrd1
Klra1
Klra4	Klra4^Chok	visible phenotype
Klra8		visible phenotype

Notes

• Experiment
  The natural killer gene complex (NKC) is located on mouse Chromosome 6 and includes greater then 2 megabases of genomic DNA. In order to map the Klra4^Chok (killer of Chinese hamster ovary cells) phenotype the authors backcrossed recombinant F2 progeny from a (BALB/c x BALB.B6-Cmv1^r)F1 x BALB/c cross. This backcrossing method allowed for the establishment of intra-NKC recombinant mouse strains that were informative to show that markers Klrd1, Klra1, Klra4^Chok and Klra8 cosegregated without recombination within the 62 cM region of mouse Chromosome 6. A fourth marker identified as Nkg2d was also shown segregating with Klra4^Chok.