Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:56630 Ferraro TN, et al., Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. J Neurosci. 1999 Aug 15;19(16):6733-9
• ID
  MGI:1345828

Genes

Gene	Assay Type
D1Mit7
Szs5	resistance/susceptibility
D1Mit11
D1Mit30
Szs1	resistance/susceptibility
D1Mit16

Notes

• Experiment
  DBA/2J and C57BL/6J mice exhibit differential sensitivity to seizure induced by pentylenetetrazol (PTZ) with DBA/2J mice being sensitive and C57BL/6J mice being relatively resistant. PTZ-induced seizure responses were studied in DBA/2J, C57BL/6J, (DBA/2Jx C57BL/6J)F1 and (DBA/2J x C57BL/6J)F2 intercross mice. QTL mapping and complementary statistical analysis identified loci on proximal (near D1Mit11) and distal (near D1Mit17) Chromosome 1. The peak LOD score on Chromosome 1 was associated with more distal markers D1Mit30 and D1Mit16 (LOD = 12.7 with 14.7% of total variance explained). The location of the peak coincides closely with the peak seen in a previously reported study (J:38888) of kainic acid-induced seizures in these strains of mice. The locus was assigned as Szs1. Candidate genes in this region include Atp1a2, Atp1b1 and Kcnj10. A second peak was detected more proximally, near markers D1Mit7 and D1Mit11 (LOD = 10.3 with 11.6% of total variance explained). This locus was designated as seizure susceptibility 5 (Szs5). A relevant candidate gene near this locus is Slc4a3. Both Szs1 and Szs5 are derived from DBA/2J-derived susceptibility alleles.