Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:55857 Lavebratt C, et al., Severity of tuberculosis in mice is linked to distal chromosome 3 and proximal chromosome 9. J Infect Dis. 1999 Jul;180(1):150-5
• ID
  MGI:1346149

Genes

Gene	Assay Type
D9Mit89
Tbs2	resistance/susceptibility

Notes

• Experiment
  Mice of the inbred strains I/StSnEgYCit and A/SnYCit show significant differences in disease severity after an intravenous injection of a lethal dose of the virulent human isolate of M. tuberculosis H37Rv. Following challenge with H37Rv, only I/St mice have rapid body weight loss and short survival times. A genome wide analysis for linkage with body weight afetr injection was done in 105 [(A/Sn x I/St)F1 x I/St] backcross mice. A locus on distal Chromosome 9, The Tbs2 locus detected here significantly overlapped the Lmr2 lcus identified in analysis of resistance to Leishmania major disease (J:40874). Possible candidates are the Mmel and Il10ra genes.