Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:52852 Mahler M, et al., Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice. Genomics. 1999 Jan 15;55(2):147-56
• ID
  MGI:1346161

Genes

Gene	Assay Type
D5Mit188
D5Mit216
Dssc1	resistance/susceptibility
D5Mit285

Notes

• Experiment
  The genetic basis for differential sensitivity of inbred mice to inflammatory bowel disease induced by dextran sulfate sodium (DSS) was investigated by crossing susceptible C3H/HeJ mice to partially resistant C57BL/6J mice. 86 (C3H/HeJ x C57BL/6J)F2 mice and 90 [(C3H/HeJ x C57BL/6J) x C57BL/6J]N2 backcross mice were analyzed for the presence of QTLs influencing DSS-induced colitis. An additive QTL on mouse Chromosome 5 between D5Mit188 and D5Mit285 (susceptibility marked by the B6 allele at D5Mit216) was significantly linked to several of the colon subphenotypes like severity, hyperplasia, ulceration, and % area involved. The confidence level for linkage of QTL to markers on Chromosome 5 exceeded the threshold for declaring significant linkage (P = 0.0000137). Possible candidate genes in the region include Selp1 and Pdgfa.