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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    5
  • Reference
    J:52898 Roper RJ, et al., Interacting quantitative trait loci control phenotypic variation in murine estradiol-regulated responses. Endocrinology. 1999 Feb;140(2):556-61
  • ID
    MGI:1346616
Genes
GeneAlleleAssay TypeDescription
D5Mit296
Estq2 visible phenotype
D5Mit388
Notes
  • Experiment
    Significant strain differences in several of the estradiol-regulated uterotropic responses have been observed suggesting that they may be genetically controlled. In this study, the authors addressed the question whether uterine growth, as determined by wet weight, is a genetically controlled phenotype. C57BL/6J and (C57BL/6J x C3H/HeJ)F1 mice responded with a greater increase in wet weight than did C3H/HeJ mice. The authors used a [(C57BL/6J x C3H/HeJ)F1 x C3H/HeJ] backcross to identify QTLs associated with uterine growth.

    Statistical analysis of the data identified as 2.39 cM region on Chromosome 5 between D5Mit296 and D5Mit388 that is significant ([a] = 0.05, threshold value = 13.39). This locus was designated as Estq2.

    Mice with C57BL/6J alleles atthe Estq2 and Estq3loci show the greatest increase in uterine weight. Putative candidates in this region include the Htr5a and Il6 genes. A model including the Estq2 locus, Estq3 locus and the interaction term between Estq3 and D10Mit180 was significant in explaining the QTLassociated with uterine weight (F = 14.256; P0.0001). This model explained 30.7% of the variation in uterine weight. This supported the hypothesis of interaction between QTL controlling estradiol-regulated responses.

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory