Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:50831 Prows DR, et al., Genetic analysis of ozone-induced acute lung injury in sensitive and resistant strains of mice. Nat Genet. 1997 Dec;17(4):471-4
• ID
  MGI:1346622

Genes

Gene	Assay Type
D11Mit179	PCR amplified length variant
Aliq1	resistance/susceptibility

Notes

• Experiment
  Mean survival time (MST) for mice exposed to ozone was analyzed in inbred strains of mice, The most variation was observed between strains A/J (A) and C57BL/6J (B) with resistance inherited as a dominant trait. Analysis of MST in AXB and BXA recombinant inbred strains (RI) showed a contimuum suggesting that more then one gene was involved in susceptibility. QTL analysis of 38 (AxB)F1 x A offspring identified a susceptibility locus on mouse Chromosome 11 2 cMs distal of D11Mit179. This susceptibility marker was identified as Aliq1.