Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:57012 Yang HT, et al., Identification of genes controlling collagen-induced arthritis in mice: striking homology with susceptibility loci previously identified in the rat. J Immunol. 1999 Sep 1;163(5):2916-21
• ID
  MGI:1346638

Genes

Gene	Assay Type
D7Mit222
Cia7	resistance/susceptibility
D7Mit234a

Notes

• Experiment
  To identify collagen-induced arthritis susceptibility loci outside of the MHC, crosses between the DBA/1 and the less susceptible B10.Q strain were analyzed.
  
  Analysis of 224 (B10.Q x DBA/1)F2 mice identified a suggestive, dominant locus, Cia7 on chromosome 7, associated with disease severity (LOD = 2.8) and incidence (p = 0.0065). Figure 2 displays the locus mapping between D7Mit222 and D7Mit234a. The disease promoting allele was dominantly inherited from the DBA/1 strain. Putative candidate genes include the Il4ra locus.