Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:57012 Yang HT, et al., Identification of genes controlling collagen-induced arthritis in mice: striking homology with susceptibility loci previously identified in the rat. J Immunol. 1999 Sep 1;163(5):2916-21
• ID
  MGI:1346639

Genes

Gene	Assay Type
D10Mit42
Cia8	resistance/susceptibility
D10Mit141

Notes

• Experiment
  To identify collagen-induced arthritis susceptibility loci outside of the MHC, crosses between the DBA/1 and the less susceptible B10.Q strain were analyzed.
  
  Analysis of 224 (B10.Q x DBA/1)F2 mice identified a suggestive, recessive locus on chromosome 10, Cia8, was associated with disease severity (LOD = 3.3) and incidence (p = 0.002). Figure 2 displays the QTL mapping between D10Mit42 and D10Mit141. The disease promoting allele inherited from the DBA/1 strain. Putative candidate genes include Col10a1,Col8a1, Col6a1 and Col6a2.