Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:52511 Akhtar RA, et al., Chromosomal linkage analysis of porphyria in mice induced by hexachlorobenzene-iron synergism: a model of sporadic porphyria cutanea tarda. Pharmacogenetics. 1998 Dec;8(6):485-94
• ID
  MGI:1346651

Genes

Gene	Assay Type
D17Mit49
Hcbip2	resistance/susceptibility
D17Mit24

Notes

• Experiment
  Human porphyrias can be modelled in iron-loaded mice exposed to hexachlorobenzene. C57BL/10ScSn is a protoytpe susceptible strain whereas DBA/2 mice are extremely resistant. A search for susceptibility loci was undertaken using QTL analysis with microsatellite markers of high and low responders from an F2 intercross. Susceptibility is defined as the accumulation of uroporphrin in the liver. Statistical analysis revealed the presence of a region on mouse Chromosome 17 between D17Mit49 and D17Mit24 associated with porphyria susceptibility (LOD = 3.6). This locus was assigned the symbol Hcbip2.