Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:57571 Ikeda A, et al., Genetic modification of hearing in tubby mice: evidence for the existence of a major gene (moth1) which protects tubby mice from hearing loss. Hum Mol Genet. 1999 Sep;8(9):1761-7
• ID
  MGI:1346656

Genes

Gene	Allele	Assay Type
Map1a	Map1a^+	visible phenotype
D2Mit17

Notes

• Experiment
  A mutation in the tub gene leads to obesity and retinal and cochlear degeneration. QTL analysis for auditory brainstem response (ABR) thresholds was carried out with (CAST/Ei.B6-tub/tub x C57BL/6J-tub/tub)F2 intercross mice to identify modifers affectinghearing ability. The marker D2Mit17 was highly associated with click ABR thresholds (P = <4.22 chi square 10e(-6), LOD = 6.0). The CAST/Ei allele of this QTL normalized ABR thresholds in tubby mice in a dominant fashion; a single copy prevented hearing loss. This QTL, designated as Mtap1a was responsible for 47% of the click threshold variance observed in this intercross.